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Seek support: Encourage patients to connect with support groups, friends, or family members who can help them stay motivated and accountable

For instance, conflicting findings on PPR-warfarin interactions highlight this complexity: some studies report PPR-mediated inhibition of warfarin metabolism, increasing plasma concentrations and anticoagulant effects (95), while others suggest diminished efficacy (91)

Efficiacy results were analysed based on the reported efficacy estimand (calculated from data gathered while patients received their assigned randomized treatment, excluding data after discontinuing the allotted medication or after adding rescue medication